Bomber, I can totally appreciate the notion that it was some random demented nocturnal animal that popped out from behind a picture hanging on the wall, scared the pants off of me then disappeared without a trace.. but in all honesty the chances it was an animal are in the millions. I'll try to prove why.
The house is a three-level duplex built in 1977 in Southern Ontario, the opposite side was occupied at the time. We never had problems with any kind of animals getting in, nor did any of our neighbors. The house had never had any problems with the roof having holes. All the windows of the house were always shut completely or left open a crack with the screen shut and locked. There is no fireplace / chimney in the house.
When I attributed the sound I heard to vaguely resembling an animal here's what I meant - What I heard was too bizarre and harsh to have come from a human. The only other logical deduction is that either a large animal somehow got into the house only to make an unearthly threatning sound at me then disappear - or that it was something supernatural.